Temporal dynamics of woolly mammoth genome erosion prior to extinction
More On Article
- A First Look at the Gravettian Open-Air Site Ollersdorf-Heidenberg (Austria): Recent Fieldwork and First Results on Stratigraphy, Chronology, Organic Preservation and Combustion Activity
- HEAS Member Publishes Article on the Gravettian Open-Air Site Ollersdorf-Heidenberg (Austria)
- Renewed impetus for Stone Age research in the eastern Free State (South Africa) centred on Rose Cottage Cave
- First farmers of Central Europe do not show family-related inequality
- Portable X-Ray Fluorescence (p-XRF) Colloquia Series - First lecture on 12th of February
Dehasque, M., Morales, H.E., Díez-del-Molino, D., Pečnerová, P., Chacón-Duque, J.C., Kanellidou, F., Muller, H., Plotnikov, V., Protopopov, A., Tikhonov, A., Nikolskiy, P., Danilov, G.K., Giannì, M., van der Sluis, L., Higham, T., Heintzman, P.D., Oskolkov, N., Gilbert, M.T.P., Götherström, A., van der Valk, T., Vartanyan, S., Dalén, L., 2024. Temporal dynamics of woolly mammoth genome erosion prior to extinction. Cell 187, 3531-3540.e3513.
Summary
A number of species have recently recovered from near-extinction. Although these species have avoided the immediate extinction threat, their long-term viability remains precarious due to the potential genetic consequences of population declines, which are poorly understood on a timescale beyond a few generations. Woolly mammoths (Mammuthus primigenius) became isolated on Wrangel Island around 10,000 years ago and persisted for over 200 generations before becoming extinct around 4,000 years ago. To study the evolutionary processes leading up to the mammoths’ extinction, we analyzed 21 Siberian woolly mammoth genomes. Our results show that the population recovered quickly from a severe bottleneck and remained demographically stable during the ensuing six millennia. We find that mildly deleterious mutations gradually accumulated, whereas highly deleterious mutations were purged, suggesting ongoing inbreeding depression that lasted for hundreds of generations. The time-lag between demographic and genetic recovery has wide-ranging implications for conservation management of recently bottlenecked populations.